Shots:

• The P-III TACKLE trial evaluates the safety & efficacy of AZD7442 (600mg- IM) as monothx. vs PBO in a ratio (1:1) in 903 outpatients aged ≥18yrs. who were non-hospitalized with COVID-19 & symptomatic for ≤7 days
• The trial met its 1EPs i.e.- 50% reduction in risk of severe COVID-19 or death from any cause- was well tolerated. In prespecified analysis- 67% reduction in risk of severe COVID-19 or death from any cause
• Additionally- 90% of patients were at high risk of progression to sev COVID-19 including co-morbidities. The company will discuss data with the authorities. On Oct 5- 2021- the company had submitted a request to the US FDA for EUA of AZD7442 to treat prophylaxis of COVID-19

Ref: AstraZeneca | Image: Al Jazeera